14,245 research outputs found

    Transcriptome analysis of the synganglion from the honey bee mite, Varroa destructor and RNAi knockdown of neural peptide targets

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    Acknowledgements This work was funded by BBSRC-LINK grant # BB/J01009X/1 and Vita Europe Ltd. We are grateful to the Scottish Beekeepers Association, especially Mr Phil McAnespie in supporting this work at its inception. We acknowledge partial funding from a Genesis Faraday SPARK Award, part of a Scottish Government SEEKIT project for the early part of this work. We are grateful to Prof David Evans for his advice on Varroa destructor viruses.Peer reviewedPostprin

    The thermal decomposition of copper (II) oxalate revisited

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    DSC, TG and TG-FT-IR, and XRPD have been used to examine the effects of supposedly inert atmospheres of argon and nitrogen on the mechanism of the thermal decomposition of copper(II) oxalate. The DSC curves in pure argon at 10 °C min[superscript −1] show a broad endotherm with onset at about 280 °C and maximum at about 295 °C. In mixtures of argon and nitrogen, as the proportion of argon gas is decreased, the endothermic character of the decomposition decreases until, when nitrogen is the main component, the decomposition exhibits a complex broad exothermic character. XRPD studies showed that, regardless of the proportions of nitrogen and argon, the DSC residues consisted of mainly copper metal with small amounts of copper(I) oxide (cuprite) and, under some conditions, traces of copper(II) oxide (tenorite). Various explanations for this behaviour are discussed and a possible answer lies in the disproportionation of CO[subscript 2](g) to form small quantities of O[subscript 2](g) or monatomic oxygen. The possibility exists that the exothermicity in nitrogen could be explained by reaction of the nitrogen with atomic oxygen to form N[subscript 2]O(g), but this product could not be detected using TG-FT-IR

    Analysis of rolling group therapy data using conditionally autoregressive priors

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    Group therapy is a central treatment modality for behavioral health disorders such as alcohol and other drug use (AOD) and depression. Group therapy is often delivered under a rolling (or open) admissions policy, where new clients are continuously enrolled into a group as space permits. Rolling admissions policies result in a complex correlation structure among client outcomes. Despite the ubiquity of rolling admissions in practice, little guidance on the analysis of such data is available. We discuss the limitations of previously proposed approaches in the context of a study that delivered group cognitive behavioral therapy for depression to clients in residential substance abuse treatment. We improve upon previous rolling group analytic approaches by fully modeling the interrelatedness of client depressive symptom scores using a hierarchical Bayesian model that assumes a conditionally autoregressive prior for session-level random effects. We demonstrate improved performance using our method for estimating the variance of model parameters and the enhanced ability to learn about the complex correlation structure among participants in rolling therapy groups. Our approach broadly applies to any group therapy setting where groups have changing client composition. It will lead to more efficient analyses of client-level data and improve the group therapy research community's ability to understand how the dynamics of rolling groups lead to client outcomes.Comment: Published in at http://dx.doi.org/10.1214/10-AOAS434 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

    Ka-band Ga-As FET noise receiver/device development

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    The development of technology for a 30 GHz low noise receiver utilizing GaAs FET devices exclusively is discussed. This program required single and dual-gate FET devices, low noise FET amplifiers, dual-gate FET mixers, and FET oscillators operating at Ka-band frequencies. A 0.25 micrometer gate FET device, developed with a minimum noise figure of 3.3 dB at 29 GHz and an associated gain of 7.4 dB, was used to fabricate a 3-stage amplifier with a minimum noise figure and associated gain of 4.4 dB and 17 dB, respectively. The 1-dB gain bandwidth of this amplifier extended from below 26.5 GHz to 30.5 GHz. A dual-gate mixer with a 2 dB conversion loss and a minimum noise figure of 10 dB at 29 GHz as well as a dielectric resonator stabilized FET oscillator at 25 GHz for the receiver L0. From these components, a hybrid microwave integrated circuit receiver was constructed which demonstrates a minimum single-side band noise figure of 4.6 dB at 29 GHz with a conversion gain of 17 dB. The output power at the 1-dB gain compression point was -5 dBm

    Bounding the distinguishing number of infinite graphs and permutation groups

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    A group of permutations G of a set V is k-distinguishable if there exists a partition of V into k cells such that only the identity permutation in G fixes setwise all of the cells of the partition. The least cardinal number k such that (G, V) is k-distinguishable is its distinguishing number, D(G, V). In particular, a graph X is k-distinguishable if its automorphism group Aut(X) satisfies D(Aut(X), VX) ≤ k. Various results in the literature demonstrate that when an infinite graph fails to have some property, then often some finite subgraph is similarly deficient. In this paper we show first that whenever an infinite connected graph X is not k-distinguishable (for a given cardinal k), then it contains a ball of finite radius whose distinguishing number is at least k. Moreover, this lower bound cannot be sharpened, since for any integer k ≥ 3 there exists an infinite, locally finite, connected graph X that is not k-distinguishable but in which every ball of finite radius is k-distinguishable. In the second half of this paper we show that a large distinguishing number for an imprimitive permutation group G is traceable to a high distinguishing number either of a block of imprimitivity or of the action induced by G on the corresponding system of imprimitiv ity. An immediate application is to automorphism groups of infinite imprimitive graphs. These results are companion to the study of the distinguishing number of infinite primitive groups and graphs in a previous paper by the authors together with T. W. Tucker

    Whole Farm Economic Evaluation of No-Till Rice Production in Arkansas

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    Rice in Arkansas is typically produced using intensive tillage. No-till rice has been studied, but the research focus has been limited to impacts on yields and per acre net returns. This analysis evaluates the profitability of no-till rice at the whole-farm level using both enterprise budget analysis and linear programming.Crop Production/Industries,

    Regional innovation in arts provision spawned by COVID-19: ‘It became a lifeline for a lot of people who are stuck at home’

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    Although the impact of the global COVID-19 pandemic on the arts and cultural sector due to the closure of galleries, museums, arts venues, and other cultural assets represents a significant health risk, new opportunities for arts and cultural engagement have arisen. Interviews with 24 representatives including service providers and creative practitioners from 15 arts and cultural organizations within the Liverpool City Region were conducted. The aim was to examine the impact of COVID-19 on arts and cultural provision and on organizations and people providing these services, as well as to understand the perceptions of service providers and practitioners of the effects on those whom arts and cultural organizations serve, including those who would usually access arts through formal healthcare routes (e.g., through collaboration with health partners). Interview data were analyzed using framework analysis. Four overarching themes were identified: Response: Closures, adaptations, and new directions; Challenges of online provision; Value of online provision; and the future of the arts. The arts and cultural sector has innovated rapidly, notably with accelerated digitalisation. Alternative provision has been “a lifeline” for vulnerable groups, such as those with mental health difficulties. Arts organizations have been most effective in reaching vulnerable, isolated and disadvantaged populations when they have worked in close collaboration with health and social care providers. The implementation of hybrid provision is an important move forward for the sector in light of our findings that alternative modes of provision are advantageous additions to service as usual. Given the increasing concerns about the mental health sequelae of the pandemic in the UK, arts and cultural engagement could play a pivotal role in the future recovery period
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